Correspondence: DNA shape is insufficient to explain binding
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چکیده
منابع مشابه
Correspondence: Reply to ‘DNA shape is insufficient to explain binding'
Transcription factors (TFs) are DNA-binding proteins that regulate gene expression. Sequence-specific TFs recognize DNA via specific amino acid-base hydrogen bonds and contacts that read local DNA shape1. Studying base and shape readout modes of TFs in vivo has been challenging due to technical issues associated with current approaches for mapping TF-binding sites (TFBSs). We recently introduce...
متن کاملCorrespondence: DNA shape is insufficient to explain binding
Proteins bind DNA through combinations of DNA base and shape recognition1. DNA base recognition refers to a unique arrangement of protein interactions with functional groups on the four DNA bases. Shape recognition refers to protein interactions with specific twists and turns of short stretches of DNA that may deviate from the average three-dimensional shape of B-form DNA. A recent study by Zen...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/ncomms15643